Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice

Abstract The nature of the effector and memory T cell response in the lungs following acute SARS-CoV-2 infections remains largely unknown. To define the pulmonary T-cell response to COVID-19, we compared effector and memory T-cell responses to SARS-CoV-2 and influenza A virus (IAV) in mice. Both vir...

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Bibliographic Details
Main Authors: Brock Kingstad-Bakke, Woojong Lee, Boyd L. Yount, Thomas Cleven, Hongtae Park, Jeremy A. Sullivan, Ralph C. Baric, M. Suresh
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07820-7