Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

Bibliographic Details
Main Authors: Liwei Chen, Jung Eun Park, Peter Paa, Priscilla D. Rajakumar, Hong-Ting Prekop, Yi Ting Chew, Swathi N. Manivannan, Wei Leong Chew
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21559-9

Internet

https://doi.org/10.1038/s41467-021-21559-9

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