FoxO3 normalizes Smad3-induced arterial smooth muscle cell growth

FoxO3 normalizes Smad3-induced arterial smooth muscle cell growth

Transition of arterial smooth muscle (ASM) from a quiescent, contractile state to a growth-promoting state is a hallmark of cardiovascular disease (CVD), a leading cause of death and disability in the United States and worldwide. While many individual signals have been identified as important mechan...

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Bibliographic Details
Main Authors: Jake T. Francisco, Andrew W. Holt, Michael T. Bullock, Madison D. Williams, Cere E. Poovey, Nathan A. Holland, Jeffrey J. Brault, David A. Tulis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Physiology
Subjects:
adenoviral overexpression
arterial smooth muscle
cardiovascular disease
FoxO3
MuRF-1
phosphorylation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1136998/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1136998/full

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