Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Abstract The alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living patients and help in diagnosing Parkinson´s disease and dementia syndromes. Our objective was to confirm that qualitative results of aSyn SAA...

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Bibliographic Details
Main Authors: Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Dementia with Lewy bodies
Parkinson’s disease
RT-QuIC
Seed amplification assay
Online Access:https://doi.org/10.1186/s40478-023-01653-3

Internet

https://doi.org/10.1186/s40478-023-01653-3

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