Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Abstract The alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living patients and help in diagnosing Parkinson´s disease and dementia syndromes. Our objective was to confirm that qualitative results of aSyn SAA...

Full description

Bibliographic Details
Main Authors:	Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Acta Neuropathologica Communications
Subjects:	Alpha-synuclein Dementia with Lewy bodies Parkinson’s disease RT-QuIC Seed amplification assay
Online Access:	https://doi.org/10.1186/s40478-023-01653-3

Similar Items

Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
by: Stefan Bräuer, et al.
Published: (2025-01-01)

Clinical, neuropathological, and molecular characteristics of rapidly progressive dementia with Lewy bodies: a distinct clinicopathological entity?
by: Giuseppe Mario Bentivenga, et al.
Published: (2024-09-01)

Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis
by: Carmen Peña-Bautista, et al.
Published: (2023-05-01)

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
by: Giovanni Bellomo, et al.
Published: (2023-04-01)

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
by: Marco J. Russo, et al.
Published: (2021-11-01)

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
by: Kathrin Brockmann, et al.
Published: (2021-10-01)

RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein
by: Ankit Srivastava, et al.
Published: (2022-04-01)

Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools
by: Silvia Paciotti, et al.
Published: (2018-06-01)

Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population
by: Jiaqi Li, et al.
Published: (2024-02-01)

Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
by: Jung-Youn Han, et al.
Published: (2021-04-01)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
by: Matthias Schmitz, et al.
Published: (2023-03-01)

Autoclave treatment fails to completely inactivate DLB alpha-synuclein seeding activity
by: Jung-Youn Han, et al.
Published: (2023-07-01)

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
by: Ivan Martinez-Valbuena, et al.
Published: (2022-02-01)

Editorial: Utility of protein aggregation assays from laboratory to clinical application
by: Alison Jane Ellen Green
Published: (2022-08-01)

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
by: Juan Huang, et al.
Published: (2024-03-01)

Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC
by: Viktoria C. Ruf, et al.
Published: (2020-05-01)

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
by: Chiara Maria Giulia De Luca, et al.
Published: (2019-08-01)

The Future of Seed Amplification Assays and Clinical Trials
by: Thomas Coysh, et al.
Published: (2022-06-01)

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies
by: Ilaria Poggiolini, et al.
Published: (2021-05-01)

Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development
by: Jiaqi Li, et al.
Published: (2022-10-01)

A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease
by: Zerui Wang, et al.
Published: (2024-10-01)

Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays
by: Matteo Manca, et al.
Published: (2020-08-01)

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
by: Niccolo Candelise, et al.
Published: (2020-01-01)

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells
by: Chiara Maria Giulia De Luca, et al.
Published: (2021-12-01)

Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids
by: Nicholas J. Haley, et al.
Published: (2017-08-01)

Diagnosing multiple system atrophy: current clinical guidance and emerging molecular biomarkers
by: Meghana Goolla, et al.
Published: (2023-09-01)

New protocol for kinetic assay seeding ability recovery “KASAR” from formalin-fixed paraffin-embedded tissues
by: Monica Hepker, et al.
Published: (2023-01-01)

RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer
by: Estela Kobashigawa, et al.
Published: (2024-04-01)

Editorial: Molecular determinants of protein assemblies in health and disease, Volume II
by: Verena Kohler, et al.
Published: (2023-12-01)

Optimization of RT-QuIC Assay Duration for Screening Chronic Wasting Disease in White-Tailed Deer
by: Gokhan Yilmaz, et al.
Published: (2024-02-01)

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients
by: Christina D. Orrù, et al.
Published: (2018-12-01)

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
by: Giulia Giannini, et al.
Published: (2022-09-01)

The Latest Research on RT-QuIC Assays—A Literature Review
by: Thi-Thu-Trang Dong, et al.
Published: (2021-03-01)

Essential Components of Synthetic Infectious Prion Formation De Novo
by: Kezia Jack, et al.
Published: (2022-11-01)

The Use of Real-Time Quaking-Induced Conversion for the Diagnosis of Human Prion Diseases
by: Anna Poleggi, et al.
Published: (2022-04-01)

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson’s Disease
by: Dong-Dong Chen, et al.
Published: (2022-07-01)

Neuropathology and molecular diagnosis of Synucleinopathies
by: Shunsuke Koga, et al.
Published: (2021-12-01)

Chronic Wasting Disease: State of the Science
by: Jason C. Bartz, et al.
Published: (2024-02-01)

Validation and Application of Skin RT-QuIC to Patients in China with Probable CJD
by: Kang Xiao, et al.
Published: (2021-12-01)

Diagnostic performance of CSF biomarkers in a well-characterized Australian cohort of sporadic Creutzfeldt-Jakob disease
by: Matteo Senesi, et al.
Published: (2023-02-01)