Cardiomyocyte dysfunction during the chronic phase of Chagas disease

Cardiomyocyte dysfunction during the chronic phase of Chagas disease

Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp techn...

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Bibliographic Details
Main Authors: Danilo Roman-Campos, Policarpo Sales-Júnior, Hugo Leonardo Duarte, Eneas Ricardo Gomes, Silvia Guatimosim, Catherine Ropert, Ricardo Tostes Gazzinelli, Jader Santos Cruz
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2013-04-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Chagas disease
calcium current
action potential
potassium current
intracellular calcium
Trypanosoma cruzi
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200243&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200243&lng=en&tlng=en

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