Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds

Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds

New 1,3,4-thiadiazole thioglycosides linked to a substituted arylidine system were synthesized via heterocyclization via click 1,3-dipolar cycloaddition. The click strategy was used for the synthesis of new 1,3,4-thiadiazole and 1,2,3-triazole hybrid glycoside-based indolyl systems as novel hybrid m...

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Bibliographic Details
Main Authors: Hussein H. Elganzory, Fahad M. Alminderej, Mohamed N. El-Bayaa, Hanem M. Awad, Eman S. Nossier, Wael A. El-Sayed
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
triazole
indole
glycosides
thiadiazole
arylacetamide
EGFR
Online Access:https://www.mdpi.com/1420-3049/27/20/6960

Internet

https://www.mdpi.com/1420-3049/27/20/6960

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