Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles

Existing optogenetic silencing methods affect membrane potential, biochemistry or protein integrity. Here, the authors demonstrate an approach for silencing synaptic transmission that combines fast activation and reversibility, by using nondisruptive, reversible, light-evoked clustering of synaptic...

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Détails bibliographiques
Auteurs principaux: Dennis Vettkötter, Martin Schneider, Brady D. Goulden, Holger Dill, Jana Liewald, Sandra Zeiler, Julia Guldan, Yilmaz Arda Ateş, Shigeki Watanabe, Alexander Gottschalk
Format: Article
Langue:English
Publié: Nature Portfolio 2022-12-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-022-35324-z