Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Abstract Background Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of patients. Stem cell-based therapies are increasingly...

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Bibliographic Details
Main Authors: Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan, Emmanuel Pinteaux
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Stem Cell Research & Therapy
Subjects:
Stroke
Human mesenchymal stem cells
Cytokines
Priming
Bone marrow-derived stromal cells
Interleukin-1
Online Access:http://link.springer.com/article/10.1186/s13287-017-0531-4

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http://link.springer.com/article/10.1186/s13287-017-0531-4

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