Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage

Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage

Renal fibrosis is a common pathological outcome of various chronic kidney diseases, and as yet, there is no specific treatment. Dapagliflozin has shown renal protection in some clinical trials as a glucose-lowering drug, but its role and mechanism on renal fibrosis remain unclear. In this study, we...

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Bibliographic Details
Main Authors: Jianhua Zeng, Hao Huang, Yan Zhang, Xin Lv, Jiawei Cheng, Si Jue Zou, Yuanyuan Han, Songkai Wang, Li Gong, Zhangzhe Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
renal fibrosis
dapagliflozin
mitochondrial damage
TGF-β1/MAPK pathway
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1095487/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1095487/full

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