Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

Abstract MLL‐rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be effective in eradicating MLL‐rearranged ALL cells in...

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Bibliographic Details
Main Authors: Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:eJHaem
Subjects:
acute lymphoblastic leukemia
chemo‐sensitizer
decitabine
DNA demethylating agent
KMT2A
MLL
Online Access:https://doi.org/10.1002/jha2.81

Internet

https://doi.org/10.1002/jha2.81

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