BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis

BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis

As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this ef...

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Bibliographic Details
Main Authors: Xiaorong Wang, Mengmeng Sang, Shengnan Gong, Zhichuan Chen, Xi Zhao, Guishuan Wang, Zhiran Li, Yingying Huang, Shitao Chen, Gangcai Xie, Enkui Duan, Fei Sun
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-07-01
Series:Genes and Diseases
Subjects:
Chromatin conformation
JQ1
scRNA-seq
Spermatid development
Spermatogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221000076

Internet

http://www.sciencedirect.com/science/article/pii/S2352304221000076

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