MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma.

MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma.

Through negative regulation of gene expression, microRNAs (miRNAs) can function as oncosuppressors in cancers, and can themselves show altered expression in various tumor types. Here, we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental processes i...

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Bibliographic Details
Main Authors: Pasqualino de Antonellis, Chiara Medaglia, Emilio Cusanelli, Immacolata Andolfo, Lucia Liguori, Gennaro De Vita, Marianeve Carotenuto, Annamaria Bello, Fabio Formiggini, Aldo Galeone, Giuseppe De Rosa, Antonella Virgilio, Immacolata Scognamiglio, Manuela Sciro, Giuseppe Basso, Johannes H Schulte, Giuseppe Cinalli, Achille Iolascon, Massimo Zollo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3171461?pdf=render

Internet

http://europepmc.org/articles/PMC3171461?pdf=render

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