Cyclosporine A Causes Gingival Overgrowth by Promoting Entry into the S Phase at the G1/S Cell Cycle Checkpoint in Gingival Fibroblasts Exposed to Lipopolysaccharide

Cyclosporine A Causes Gingival Overgrowth by Promoting Entry into the S Phase at the G1/S Cell Cycle Checkpoint in Gingival Fibroblasts Exposed to Lipopolysaccharide

Objectives: Cyclosporine A promotes gingival fibrosis by enhancing the proliferation of gingival fibroblasts, leading to gingival overgrowth. The population of gingival fibroblasts is regulated by cell cycle machinery, which balances cell growth and inhibition. Cells that detect DNA damage pause at...

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Bibliographic Details
Main Authors: Reiri Takeuchi, Noriko Kuwahara, Yuta Amino, Sachiyo Hayashi, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Teruaki Nagashima, Kazumune Arikawa, Yuichiro Okada, Takato Nomoto, Koichi Hiratsuka
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Diseases
Subjects:
gingival overgrowth
cyclosporine A
gingival fibroblast
cell cycle
G1/S checkpoint
S-phase entry
Online Access:https://www.mdpi.com/2079-9721/12/12/322

Internet

https://www.mdpi.com/2079-9721/12/12/322

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