Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5mC is well-established, the specific functions of 5...

Full description

Bibliographic Details
Main Authors: Srivarsha Rajshekar, Jun Yao, Paige K Arnold, Sara G Payne, Yinwen Zhang, Teresa V Bowman, Robert J Schmitz, John R Edwards, Mary Goll
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
DNA methylation
pericentromeres
ICF Syndrome
interferon response
Online Access:https://elifesciences.org/articles/39658

Internet

https://elifesciences.org/articles/39658

Similar Items