Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cellsResearch in context

Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cellsResearch in context

Background: We have revealed that neuropilin-1 (NRP-1) promoted hepatic stellate cell activation and liver fibrosis through its profibrogenic signalling pathways. However, the role of NRP-1 in angiogenesis in hepatic sinusoidal endothelial cells (HSECs) during liver cirrhosis remains unclear. Method...

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Bibliographic Details
Main Authors: Le Wang, Yuemin Feng, Xiaoyu Xie, Hao Wu, Xiao Nan Su, Jianni Qi, Wei Xin, Lifen Gao, Ying Zhang, Vijay H. Shah, Qiang Zhu
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302890

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http://www.sciencedirect.com/science/article/pii/S2352396419302890

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