Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification

Abstract The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic functions). Unlike Tet1 and Tet2, Tet3 is no...

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Bibliographic Details
Main Authors: Harmony C. Ketchum, Masako Suzuki, Meelad M. Dawlaty
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06120-w