Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1 axis

Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1 axis

Skeletal system toxicity due to lead exposure has attracted extensive attention in recent years, but few studies focus on the skeletal toxicity of lead in the early life stages of zebrafish. The endocrine system, especially the GH/IGF-1 axis, plays an important role in bone development and bone heal...

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Bibliographic Details
Main Authors: Rui Yan, Jie Ding, Qianlei Yang, Xiaoyun Zhang, Junyu Han, Tingxu Jin, Shudi Shi, Xirui Wang, Yu Zheng, Heran Li, Hengdong Zhang, Yan An
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Lead acetate
GH/IGF-1 axis
Cartilage defects
Bone loss
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323001707

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http://www.sciencedirect.com/science/article/pii/S0147651323001707

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