Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency

Two of the most prevalent ovarian diseases affecting women’s fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can promote the epigenetic transgenerational inheritance...

Full description

Bibliographic Details
Main Authors: Eric Nilsson, Rachel Klukovich, Ingrid Sadler-Riggleman, Daniel Beck, Yeming Xie, Wei Yan, Michael K. Skinner
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:Epigenetics
Subjects:
ovary
granulosa
epigenetic
transgenerational
sperm
dna methylation
ncrna
transcriptome
pco disease
poi
Online Access:http://dx.doi.org/10.1080/15592294.2018.1521223

Internet

http://dx.doi.org/10.1080/15592294.2018.1521223

Similar Items