Site-specific ubiquitylation acts as a regulator of linker histone H1

While the role of specific posttranslational modifications (PTMs) is increasingly well understood for core histones, this is not the case for linker histone H1. Here the authors show that site-specific ubiquitylation of H1 results in distinct interactomes, regulates phase separation, and modulates a...

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Bibliographic Details
Main Authors: Eva Höllmüller, Simon Geigges, Marie L. Niedermeier, Kai-Michael Kammer, Simon M. Kienle, Daniel Rösner, Martin Scheffner, Andreas Marx, Florian Stengel
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23636-5