Role of endothelin in cardiovascular disease
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstricto...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2002-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2002.001 |
| _version_ | 1797282340893884416 |
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| author | Alexei V Agapitov William G Haynes |
| author_facet | Alexei V Agapitov William G Haynes |
| author_sort | Alexei V Agapitov |
| collection | DOAJ |
| description | Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system (RAAS), vasopressin and atrial natriuretic peptide and stimulates the sympathetic nervous system. The overall action of endothelin is to increase blood pressure and vascular tone. Therefore, endothelin antagonists may play an important role in the treatment of cardiac, vascular and renal diseases associated with regional or systemic vasoconstriction and cell proliferation, such as essential hypertension, pulmonary hypertension, chronic heart failure and chronic renal failure. Long-term anti-endothelin therapy may improve symptoms and favourably alter the progression of heart failure. Endothelin appears to participate in induction and progression of sclerotic renal changes, leading to progression to end-stage renal disease. Anti-endothelin therapy might offer additional benefits in the prevention of progression of chronic renal failure in addition to the known benefits of RAAS inhibition. Clinical trials have demonstrated potentially important benefits of endothelin antagonists for patients with essential hypertension, pulmonary hypertension and heart failure. Further studies are necessary to determine the role of anti-endothelin therapy in the treatment of cardiovascular diseases and determine the different roles of selective receptor antagonism vs . mixed ET A/B -receptor antagonism in human diseases. |
| first_indexed | 2024-03-07T17:11:25Z |
| format | Article |
| id | doaj.art-17bf9f4d02da4bf9a05288881f054848 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:11:25Z |
| publishDate | 2002-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-17bf9f4d02da4bf9a05288881f0548482024-03-03T00:53:25ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032002-03-01310.3317/jraas.2002.001Role of endothelin in cardiovascular diseaseAlexei V AgapitovWilliam G HaynesEndothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system (RAAS), vasopressin and atrial natriuretic peptide and stimulates the sympathetic nervous system. The overall action of endothelin is to increase blood pressure and vascular tone. Therefore, endothelin antagonists may play an important role in the treatment of cardiac, vascular and renal diseases associated with regional or systemic vasoconstriction and cell proliferation, such as essential hypertension, pulmonary hypertension, chronic heart failure and chronic renal failure. Long-term anti-endothelin therapy may improve symptoms and favourably alter the progression of heart failure. Endothelin appears to participate in induction and progression of sclerotic renal changes, leading to progression to end-stage renal disease. Anti-endothelin therapy might offer additional benefits in the prevention of progression of chronic renal failure in addition to the known benefits of RAAS inhibition. Clinical trials have demonstrated potentially important benefits of endothelin antagonists for patients with essential hypertension, pulmonary hypertension and heart failure. Further studies are necessary to determine the role of anti-endothelin therapy in the treatment of cardiovascular diseases and determine the different roles of selective receptor antagonism vs . mixed ET A/B -receptor antagonism in human diseases.https://doi.org/10.3317/jraas.2002.001 |
| spellingShingle | Alexei V Agapitov William G Haynes Role of endothelin in cardiovascular disease Journal of the Renin-Angiotensin-Aldosterone System |
| title | Role of endothelin in cardiovascular disease |
| title_full | Role of endothelin in cardiovascular disease |
| title_fullStr | Role of endothelin in cardiovascular disease |
| title_full_unstemmed | Role of endothelin in cardiovascular disease |
| title_short | Role of endothelin in cardiovascular disease |
| title_sort | role of endothelin in cardiovascular disease |
| url | https://doi.org/10.3317/jraas.2002.001 |
| work_keys_str_mv | AT alexeivagapitov roleofendothelinincardiovasculardisease AT williamghaynes roleofendothelinincardiovasculardisease |