BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.

Bibliographic Details
Main Authors: Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16040

Internet

https://doi.org/10.1038/ncomms16040

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