BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms16040 |
| _version_ | 1818855836366143488 |
|---|---|
| author | Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras |
| author_facet | Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras |
| author_sort | Adonia E. Papathanassiu |
| collection | DOAJ |
| description | BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats. |
| first_indexed | 2024-12-19T08:14:56Z |
| format | Article |
| id | doaj.art-17c2e0ed5041454ca875e7539e4aa551 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:14:56Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-17c2e0ed5041454ca875e7539e4aa5512022-12-21T20:29:31ZengNature PortfolioNature Communications2041-17232017-07-018111310.1038/ncomms16040BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseasesAdonia E. Papathanassiu0Jeong-Hun Ko1Martha Imprialou2Marta Bagnati3Prashant K. Srivastava4Hong A. Vu5Danilo Cucchi6Stephen P. McAdoo7Elitsa A. Ananieva8Claudio Mauro9Jacques Behmoaras10Ergon PharmaceuticalsCentre for Complement and Inflammation Research, Imperial College LondonCentre for Complement and Inflammation Research, Imperial College LondonCentre for Complement and Inflammation Research, Imperial College LondonDivision of Brain Sciences, Imperial College Faculty of MedicineErgon PharmaceuticalsWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonDepartment of Medicine, Renal and Vascular Inflammation Section, Imperial College LondonBiochemistry and Nutrition, Des Moines UniversityWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Complement and Inflammation Research, Imperial College LondonBCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.https://doi.org/10.1038/ncomms16040 |
| spellingShingle | Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases Nature Communications |
| title | BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| title_full | BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| title_fullStr | BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| title_full_unstemmed | BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| title_short | BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| title_sort | bcat1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases |
| url | https://doi.org/10.1038/ncomms16040 |
| work_keys_str_mv | AT adoniaepapathanassiu bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT jeonghunko bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT marthaimprialou bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT martabagnati bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT prashantksrivastava bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT hongavu bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT danilocucchi bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT stephenpmcadoo bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT elitsaaananieva bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT claudiomauro bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases AT jacquesbehmoaras bcat1controlsmetabolicreprogramminginactivatedhumanmacrophagesandisassociatedwithinflammatorydiseases |