Mitochondria-targeted derivative of pterostilbene, a dietary phytoestrogen, exhibits superior cancer cell cytotoxicity via mitochondrial superoxide mediated induction of autophagy

Mitochondria-targeted derivative of pterostilbene, a dietary phytoestrogen, exhibits superior cancer cell cytotoxicity via mitochondrial superoxide mediated induction of autophagy

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene;PTS), a dimethyl ether analogue of resveratrol, has been shown to possess anti-bacterial, anti-cancer, anti-inflammatory and antioxidant properties. In the present study, we have synthesized a mitochondria targeted derivative of Pterostilbene (M-P...

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Bibliographic Details
Main Authors: Mahin K. Ibrahim, Shivani R. Nandha, Ashwani S. Patil, Sadhana Sathaye, Mariam S. Degani, Binita Kumar, Rahul Checker, Deepak Sharma, Santosh K. Sandur
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Advances in Redox Research
Subjects:
Apoptosis
Clonogenic potential
Reactive oxygen species
Triphenylphosphonium
Natural product
Online Access:http://www.sciencedirect.com/science/article/pii/S2667137923000115

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http://www.sciencedirect.com/science/article/pii/S2667137923000115

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