The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the key active regions of sAPPα is the central APP dom...

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Bibliographic Details
Main Authors: Jodi A. Morrissey, Erin Bigus, Julie C. Necarsulmer, Vinay Srinivasan, Katie Peppercorn, Daniel J. O’Leary, Bruce G. Mockett, Warren P. Tate, Stephanie M. Hughes, Karen D. Parfitt, Wickliffe C. Abraham
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
amyloid precursor protein
amyloid-beta
long-term potentiation
field excitatory postsynaptic potential
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00459/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00459/full

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