Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Abstract Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly neutralizing antibodies (bNAbs) is hindered by extensive sequence diversity and low immunogenicity of envelope glycoprotein vaccine candidates, most notably soluble E2 (sE2). To overcome this, we employed two-c...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
Nature Portfolio
2022-11-01
|
| 丛编: | npj Vaccines |
| 在线阅读: | https://doi.org/10.1038/s41541-022-00570-1 |