Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers

Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers

Abstract Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly neutralizing antibodies (bNAbs) is hindered by extensive sequence diversity and low immunogenicity of envelope glycoprotein vaccine candidates, most notably soluble E2 (sE2). To overcome this, we employed two-c...

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Bibliographic Details
Main Authors: Jannick Prentoe, Christoph M. Janitzek, Rodrigo Velázquez-Moctezuma, Andreas Soerensen, Thomas Jørgensen, Stine Clemmensen, Vladislav Soroka, Susan Thrane, Thor Theander, Morten A. Nielsen, Ali Salanti, Jens Bukh, Adam F. Sander
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00570-1

Internet

https://doi.org/10.1038/s41541-022-00570-1

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