Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism

Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism

Abstract Increasing evidence supports the hypothesis that cancer progression is under mitochondrial control. Mitochondrial fission plays a pivotal role in the maintenance of cancer cell homeostasis. The inhibition of DRP1, the main regulator of mitochondrial fission, with the mitochondrial division...

Descrizione completa

Dettagli Bibliografici
Autori principali: Eduardo Silva-Pavez, Elizabeth Mendoza, Pablo Morgado-Cáceres, Ulises Ahumada-Castro, Galdo Bustos, Matías Kangme-Encalada, Amaia Lopez de Arbina, Andrea Puebla-Huerta, Felipe Muñoz, Lucas Cereceda, Manuel Varas-Godoy, Yessia Hidalgo, J. Cesar Cardenas
Natura: Articolo
Lingua:English
Pubblicazione: Nature Portfolio 2024-06-01
Serie:Scientific Reports
Soggetti:
Mdivi-1
Cell detachment
Mitochondrial complex I
Cancer
Metabolism
Accesso online:https://doi.org/10.1038/s41598-024-64228-9

Accesso online

https://doi.org/10.1038/s41598-024-64228-9

Documenti analoghi