The Use of a Humanized NSG-β2m−/− Model for Investigation of Immune and Anti-tumor Effects Mediated by the Bifunctional Immunotherapeutic Bintrafusp Alfa

The Use of a Humanized NSG-β2m−/− Model for Investigation of Immune and Anti-tumor Effects Mediated by the Bifunctional Immunotherapeutic Bintrafusp Alfa

The lack of serial biopsies in patients with a range of carcinomas has been one obstacle in our understanding of the mechanism of action of immuno-oncology agents as well as the elucidation of mechanisms of resistance to these novel therapeutics. While much information can be obtained from studies c...

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Bibliographic Details
Main Authors: Y. Maurice Morillon, Claire Smalley Rumfield, Samuel T. Pellom, Ariana Sabzevari, Nicholas T. Roller, Lucas A. Horn, Caroline Jochems, Claudia Palena, John W. Greiner, Jeffrey Schlom
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
humanized mouse
NSG-β2m−/−
bintrafusp alfa
immunotherapy
TGF-β
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00549/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00549/full

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