Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing

Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing

IntroductionWhile tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determine if long-read sequencing could be used to accurately quantify allele-specific HLA trans...

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Bibliographic Details
Main Authors: Andrew E. O. Hughes, Maureen C. Montgomery, Chang Liu, Eric T. Weimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
human leukocyte antigen (HLA)
nanopore sequencing
long-read sequencing
transcript isoforms
allele-specific expression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199618/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199618/full

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