Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling

Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling

Acute myeloid leukemia (AML) is a high-mortality malignancy with poor outcomes. Azacitidine induces cell death and demonstrates treatment effectiveness against AML. Selinexor (KPT-330) exhibited significant benefits in combination with typical induction treatment for AML patients. Here, we explore t...

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Bibliographic Details
Main Authors: Huideng Long, Yue Hou, Jun Li, Chunhua Song, Zheng Ge
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
XPO-1 inhibitor
azacitidine
acute myeloid leukemia
apoptosis
eIF4E
c-MYC
Online Access:https://www.mdpi.com/1422-0067/24/7/6816

Internet

https://www.mdpi.com/1422-0067/24/7/6816

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