Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF<sup>V600E</sup> Dual Inhibitors Endowed with Antiproliferative Activity
2,3,4-trisubstituted thiazoles <b>3a</b>–<b>i</b>, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et<sub>3</sub>N at room temperature or in ethanol under reflux....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/7/1014 |