Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats

Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats

L-DOPA-induced dyskinesia (LID) represents one of the major problems of the long-term therapy of patients with Parkinson's disease (PD). Although, the pathophysiologic mechanisms underlying LID are not completely understood, activation of the extracellular signal regulated kinase (ERK) is recog...

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Bibliographic Details
Main Authors: Guiqin Chen, Shuke Nie, Chao Han, Kai Ma, Yan Xu, Zhentao Zhang, Stella M. Papa, Xuebing Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson's disease
L-DOPA-induced dyskinesia
p-ERK1/2
ΔFosB
TH
ARNT
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00112/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00112/full

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