Harnessing machine learning to find synergistic combinations for FDA-approved cancer drugs

Abstract Combination therapy is a fundamental strategy in cancer chemotherapy. It involves administering two or more anti-cancer agents to increase efficacy and overcome multidrug resistance compared to monotherapy. However, drug combinations can exhibit synergy, additivity, or antagonism. This stud...

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Váldodahkkit: Tarek Abd El-Hafeez, Mahmoud Y. Shams, Yaseen A. M. M. Elshaier, Heba Mamdouh Farghaly, Aboul Ella Hassanien
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Nature Portfolio 2024-01-01
Ráidu:Scientific Reports
Liŋkkat:https://doi.org/10.1038/s41598-024-52814-w