The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN), the main alkaloid from DC, possesses a furan...

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Bibliographic Details
Main Authors: Zhuo-Qing Li, Li-Long Jiang, Dong-Sheng Zhao, Jing Zhou, Ling-Li Wang, Zi-Tian Wu, Xian Zheng, Zi-Qi Shi, Ping Li, Hui-Jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
Dictamni Cortex
dictamnine
liver injury
CYP3A4
induction/inhibition effect
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01033/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01033/full

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