Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis

Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis

Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection. Matrix metalloproteinase-1 plays a crucial role in the immunopathology of TB, causing breakdown of type I collagen and cavitation, but this...

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Bibliographic Details
Main Authors: Sara Brilha, Deborah L. W. Chong, Akif A. Khawaja, Catherine W. M. Ong, Naomi J. Guppy, Joanna C. Porter, Jon S. Friedland
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
extracellular matrix
respiratory epithelial cell
matrix metalloproteinases
integrins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01348/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01348/full

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