Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

Background & Aims: The constitutive androstane receptor (CAR) is a nuclear receptor that binds diverse xenobiotics and whose activation leads to the modulation of the expression of target genes involved in xenobiotic detoxification and energy metabolism. Although CAR hepatic activity is cons...

Full description

Bibliographic Details
Main Authors: Marine Huillet, Frédéric Lasserre, Marie-Pierre Gratacap, Beatrice Engelmann, Justine Bruse, Arnaud Polizzi, Tiffany Fougeray, Céline Marie Pauline Martin, Clémence Rives, Anne Fougerat, Claire Naylies, Yannick Lippi, Géraldine Garcia, Elodie Rousseau-Bacquie, Cécile Canlet, Laurent Debrauwer, Ulrike Rolle-Kampczyk, Martin von Bergen, Bernard Payrastre, Elisa Boutet-Robinet, Laurence Gamet-Payrastre, Hervé Guillou, Nicolas Loiseau, Sandrine Ellero-Simatos
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JHEP Reports
Subjects:
Sexual dimorphism
Hepatic xenobiotic metabolism
Lipoprotein metabolism
Platelet aggregation
Trimethylamine-N-oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002616

Internet

http://www.sciencedirect.com/science/article/pii/S2589555923002616

Similar Items