Sustained increased CaMKII phosphorylation is involved in the impaired regression of isoproterenol-induced cardiac hypertrophy in rats

Sustained increased CaMKII phosphorylation is involved in the impaired regression of isoproterenol-induced cardiac hypertrophy in rats

To understand the mechanism underlying the regression of cardiac hypertrophy, we investigated the pathological changes after isoproterenol (ISO) withdrawal in ISO-induced cardiomyopathy models in rats and neonatal cardiomyocytes. Cardiac hypertrophy was induced in rats by two weeks of ISO administra...

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Bibliographic Details
Main Authors: Jingyuan Li, Qinghua Gao, Siqi Wang, Ze Kang, Zhuo Li, Shuai Lei, Xuefei Sun, Meimi Zhao, Xiye Chen, Guangyu Jiao, Huiyuan Hu, Liying Hao
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Cardiac hypertrophy
Regression
Sustained
Calmodulin-dependent protein kinase II
CaV1.2 channel
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300657

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http://www.sciencedirect.com/science/article/pii/S1347861320300657

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