Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Abstract Background Meningococcal meningitis (MM) is a life-threatening disease associated with approximately 10% case fatality rates and neurological sequelae in 10–20% of the cases. Recently, we have shown that the matrix metalloproteinase (MMP) inhibitor BB-94 reduced brain injury in a mouse mode...

Full description

Bibliographic Details
Main Authors: Susanna Ricci, Denis Grandgirard, Ilias Masouris, Tiziana Braccini, Gianni Pozzi, Marco R. Oggioni, Uwe Koedel, Stephen L. Leib
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Infectious Diseases
Subjects:
Neisseria meningitidis
Meningococcal meningitis
Mouse model
Doxycycline
Adjunctive therapy
Brain damage
Online Access:http://link.springer.com/article/10.1186/s12879-020-05226-w

Internet

http://link.springer.com/article/10.1186/s12879-020-05226-w

Similar Items