Microenvironment‐induced restoration of cohesive growth associated with focal activation of P‐cadherin expression in lobular breast carcinoma metastatic to the colon

Microenvironment‐induced restoration of cohesive growth associated with focal activation of P‐cadherin expression in lobular breast carcinoma metastatic to the colon

Abstract Invasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E‐cadherin loss. Focal activation of P‐cadherin expression in tumor cells that are deficient for E‐cadherin occurs in a subset of ILCs. Switching from an E‐cadherin deficient to P‐cadher...

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Bibliographic Details
Main Authors: Malte Gronewold, Isabel Grote, Stephan Bartels, Henriette Christgen, Leonie D Kandt, Maria Jose Brito, Gàbor Cserni, Maximilian E Daemmrich, Franz Fogt, Burkhard M Helmke, Natalie terHoeve, Corinna Lang‐Schwarz, Michael Vieth, Axel Wellmann, Elna Kuehnle, Ulf Kulik, Gesa Riedel, Tanja Reineke‐Plaass, Ulrich Lehmann, Thijs Koorman, Patrick WB Derksen, Hans Kreipe, Matthias Christgen
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:The Journal of Pathology: Clinical Research
Subjects:
lobular breast cancer
cadherin switching
growth pattern
variants
tumor‐stroma‐interaction
Online Access:https://doi.org/10.1002/2056-4538.12361

Internet

https://doi.org/10.1002/2056-4538.12361

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