The influence of immortal time bias in observational studies examining associations of antifibrotic therapy with survival in idiopathic pulmonary fibrosis: A simulation study

The influence of immortal time bias in observational studies examining associations of antifibrotic therapy with survival in idiopathic pulmonary fibrosis: A simulation study

BackgroundImmortal time bias (ITB) has been overlooked in idiopathic pulmonary fibrosis (IPF). We aimed to identify the presence of ITB in observational studies examining associations between antifibrotic therapy and survival in patients with IPF and illustrate how ITB may affect effect size estimat...

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Bibliographic Details
Main Authors: Qiang Zheng, Petr Otahal, Ingrid A. Cox, Barbara de Graaff, Julie A. Campbell, Hasnat Ahmad, E. Haydn Walters, Andrew J. Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Medicine
Subjects:
immortal time bias
idiopathic pulmonary fibrosis
time–dependent
landmark
observational research
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1157706/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1157706/full

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