Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice

Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice

Summary: Generating effective therapies for neurodevelopmental disorders has remained elusive. An emerging drug discovery approach for neurodevelopmental disorders is to characterize transcriptome-wide dysregulation in an appropriate model system and screen therapeutics based on their capacity to re...

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Bibliographic Details
Main Authors: Andrew K. Ressler, Gabriela L.A. Sampaio, Sarah A. Dugger, Tamar Sapir, Daniel Krizay, Michael J. Boland, Orly Reiner, David B. Goldstein
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Psychiatry
Biological sciences
Developmental biology
Embryology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222020703

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http://www.sciencedirect.com/science/article/pii/S2589004222020703

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