Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways

Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways

IntroductionPolycystic ovary syndrome (PCOS) is a complex disorder characterized by metabolic and ovulatory dysfunctions, often associated with an imbalance in gut microbiota. Despite current treatments, effective management strategies targeting underlying mechanisms remain limited.MethodsIn this st...

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Bibliographic Details
Main Authors: Yating Xu, Li Ning, Yu Si, Xiu Li, Ruyue Wang, Qingling Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Endocrinology
Subjects:
polycystic ovary syndrome
AMP-activated protein kinase
Indole-3-carboxaldehyde
gut microbiota
serum metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1526109/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2025.1526109/full

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