The G285S mutation in nsP1 is sufficient to render Sindbis virus as a stable vector for gene delivery

The G285S mutation in nsP1 is sufficient to render Sindbis virus as a stable vector for gene delivery

Neuroscience, gene therapy, and vaccine have all benefited from the increased use of viral vectors. Sindbis virus (SINV) is a notable candidate among these vectors. However, viral vectors commonly suffer from a loss of expression of the transgene, especially RNA viral vectors. In this study, we used...

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Bibliographic Details
Main Authors: Xiangwei Shi, Kangyixin Sun, You Hu, Qinghan Wang, Guoyang Liao, Li Li, Pengjie Wen, Leo E. Wong, Fan Jia, Fuqiang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Microbiology
Subjects:
Sindbis virus
directed evolution
adaptive mutation
stable vector
gene delivery
neural circuits
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1229506/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1229506/full

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