IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer

IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer

Background: Colorectal cancer is a commonly diagnosed cancer with high mortality worldwide. Postoperative recidivation and metastasis still are the main challenges in clinical treatments. Thus, it is urgent to develop new therapies against colorectal cancer. Epithelial Cell Adhesion Molecule (EpCAM)...

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Bibliographic Details
Main Authors: Lei Wang, Yu Qiao, Huifang Zong, Lei Han, Yong Ke, ZhiDi Pan, Jie Chen, Jun Lu, Jinyao Li, Tianlei Ying, Baohong Zhang, Jianwei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
bispecific antibody
split intein
epcam
CD3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.803059/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.803059/full

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