Generation of Tumor-Specific Cytotoxic T Cells From Blood via In Vitro Expansion Using Autologous Dendritic Cells Pulsed With Neoantigen-Coupled Microbeads

Generation of Tumor-Specific Cytotoxic T Cells From Blood via In Vitro Expansion Using Autologous Dendritic Cells Pulsed With Neoantigen-Coupled Microbeads

For the past decade, adoptive cell therapy including tumor-infiltrating lymphocytes, genetically modified cytotoxic lymphocytes expressing a chimeric antigen receptor, or a novel T-cell receptor has revolutionized the treatment of many cancers. Progress within exome sequencing and neoantigen predict...

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Bibliographic Details
Main Authors: Adela Kiessling, Keerthana Ramanathan, Ola B. Nilsson, Luigi Notari, Stefanie Renken, Rolf Kiessling, Hans Grönlund, Stina L. Wickström
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
neoantigen
tumor-specific antigens
autologous tumor recognition
dendritic cell-mediated activation
personalized cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.866763/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.866763/full

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