Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

Abstract Background Due to its high stress tolerance and low acetate secretion, Escherichia coli W is reported to be a good production host for several metabolites and recombinant proteins. However, simultaneous co-utilization of glucose and other substrates such as acetate remains a challenge. The...

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Bibliographic Details
Main Authors: Katharina Novak, Lukas Flöckner, Anna Maria Erian, Philipp Freitag, Christoph Herwig, Stefan Pflügl
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Microbial Cell Factories
Subjects:
E. coli W
Acetyl-CoA-synthetase
Acetate (Acs)
Metabolic engineering
Protein acetylation
Biomass composition
Online Access:http://link.springer.com/article/10.1186/s12934-018-0955-2

Internet

http://link.springer.com/article/10.1186/s12934-018-0955-2

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