Chemical Modifications Influence the Number of siRNA Molecules Adsorbed on Gold Nanoparticles and the Efficiency of Downregulation of a Target Protein

Chemical Modifications Influence the Number of siRNA Molecules Adsorbed on Gold Nanoparticles and the Efficiency of Downregulation of a Target Protein

Small interfering RNAs (siRNAs) are a powerful tool for specific suppression of protein synthesis in the cell, and this determines the attractiveness of siRNAs as a drug. Low resistance of siRNA to nucleases and inability to enter into target cells are the most crucial issues in developing siRNA-bas...

Full description

Bibliographic Details
Main Authors: Anna V. Epanchintseva, Julia E. Poletaeva, Anton S. Dome, Ilya S. Dovydenko, Inna A. Pyshnaya, Elena I. Ryabchikova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Nanomaterials
Subjects:
modified siRNA
phosphoryl guanidine modification
siRNA adsorption on AuNPs
multilevel nanoconstruct
efficiency of silencing
Online Access:https://www.mdpi.com/2079-4991/12/24/4450

Internet

https://www.mdpi.com/2079-4991/12/24/4450

Similar Items