Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Alzheimer’s disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given the limi...

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Bibliographic Details
Main Authors: Lazhar Zribi, Irene Pachòn-Angona, Òscar M. Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, Lhassane Ismaili, Isabel Iriepa, Fakher Chabchoub
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
antioxidants
cholinesterase inhibitors
ORAC
triazolopyridopyrimidine
Online Access:https://www.mdpi.com/1420-3049/25/14/3190

Internet

https://www.mdpi.com/1420-3049/25/14/3190

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