Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

Abstract Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the recently approved oral hypoglycemic mixture; metformin (MET) and canagliflozin (CFZ) in human plasma using propranolol HCl (PPL)...

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Bibliographic Details
Main Authors: Dalia Mohamed, Mona S. Elshahed, Tamer Nasr, Nageh Aboutaleb, Ola Zakaria
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Chemistry
Subjects:
Metformin
Canagliflozin
HPLC–MS/MS
Human plasma
Pharmacokinetic study
Online Access:http://link.springer.com/article/10.1186/s13065-019-0597-4

Internet

http://link.springer.com/article/10.1186/s13065-019-0597-4

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