Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

BackgroundActivated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart functio...

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Bibliographic Details
Main Authors: Maria Raquel Moita, Marta M. Silva, Cláudia Diniz, Margarida Serra, René M. Hoet, Ana Barbas, Daniel Simão
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibroblast
cardiac fibrosis
myofibroblast
transcriptomic
quantitative proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1015473/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1015473/full

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